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Triple-Blind Randomized Placebo Controlled Research of the Effect of StemEnhance™ on Bone Marrow Stem Cell Mobilization.¹ 1. This is an essence of a full fledge study report got ready for publication in the peer-review scientific literature. METHODS Consumables Volunteers * Bellow 20 or more than more than 65 years of age When the volunteers arrived, they were seated in quiet and calm areas. They were also instructed to remain quiescent, comfortably sitting in a chair, for one hour. Just after taking the baseline sample, a consumable was given to them. They all were instructed to remain quiescent for the whole period of the trial. Later on, blood samples were taken after 30, 60 and 120 minutes of ingestion of the consumable. Estimation of circulating stem cells
As it is obvious that the overall time for the absorption of bioactive components, delivery to desired organs, and the production a proven physiological response may be different based on overall physiology of every volunteer, we calculated the optimum response of SE at any one point in time. It was done within 60 minutes of consumption. A 24 ± 5 % increase (median = 27%) in the number of circulating stem cells was recorded with SE. The standard maximum response boosts to 30 ± 6% if we include data taken during a dose study performed in May 2005. Figure 1. Total time according to the number of CD34+ cells in peripheral blood after taking (arrow) of SE and placebo (Crtl). Data is shown as % of starting value. Bars reveal about standard error. DISCUSSION Physiological relevance of the observed stem cell mobilization The newness of the idea of using endogenous release of bone marrow stem cells to support maximum health condition goes side by side with a shortage of data linking the magnitude of mobilization with physiological relevance. On the other hand, data exist to guess the physiological relevance of putting into circulation 3.5 million new stem cells. Replying on a number of studies (Orlic et al. 2001; Bodine et al., 1994; Bodine et al. 1993; Vandelverde et al., 2005; Valgimigli et al., 2005) one can calculate roughly that one gram of StemEnhance can lead to potentially of up to a few billion somatic cells in target tissues. For that reason, the standard raise of 25% to 30% found with SE in this study is probably to have physiological relevance. REFERENCES Bodine DM, Seidel NE, Zsebo KM, and Orlic D. (1993) In Vivo Administration of Stem Cell Factor to Mice Increases the Absolute Number of Pluripotent Hematopoietic Stem Cells. Blood, 82(2): 445- 455. Orlic D, Kajstura J, Chimenti S, Bodine DM, Leri A. & Anversa P. (2003) Bone marrow stem cells regenerate infarcted myocardium. Pediatr Transplantation 7 (Suppl. 3): 86–88. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A. & Anversa P. (2001) Mobilized bone marrow cells repair the infracted heart, improving function and survival. PNAS 98(18):10344–10349. Valgimigli M, Rigolin GM, Cittanti C, Malagutti P, Curello S, Percoco G, Bugli AM, Porta MD, Bragotti LZ, Ansani L, Mauro E, Lanfranchi A, Giganti M, Feggi L, Castoldi G, Ferrari R. (2005) Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: clinical and angiographic safety profile. Eur Heart J. Apr 28. Epub. ABOUT CHRISTIAN DRAPEAU, MSc Depending on the research he produced and information he studied from other a number of scientific teams, recently Mr. Drapeau and his collaborators together suggested and published a breakthrough idea on adult stem cell physiology. This theory is also the co-inventor of StemEnhance™. Mr. Drapeau got his degree of bachelors in Neurophysiology from McGill University, Montreal, in 1987. He got his degree of masters from the Department of Neurology and Neurosurgery from the Montreal Neurological Institute, McGill University, Montreal, in 1991. (Gathered from research articles, science papers and medical publications). Stem Cells From Muscles Can Repair Cartilage The President's Council on Bioethics: Adult Stem Cells Stem Cell Therapy in Perspective Clinical Applications of Blood-Derived and Marrow-Derived Stem Cells for Nonmalignant Diseases . JAMA Vol.299 No. 8, February 27, 2008 Bone marrow stem cells can participate in cutaneous healing, contributing to wound healing - Journal of Cellular Physiology 196, 245-250; 2003 Stem cells participate in the generation of new neurons within the human brain - Proceedings of the National Academy of Sciences USA 100, 1364-1369; 4 Feb 2003 Mobilized stem cells have also been used in renewal of cardiac tissue - Journal of Clinical Investigation 107, 1395-1402; Jun 2001 Bone marrow stem cells have also shown the ability to participate in renewal of retinal tissues - Nature Medicine 8, 1004-1010; Sep 2002 |
Taking SE became a cause of increase in the number of circulating CD34+ cells, whereas consumption of the placebo did not cause any statistically important effect.